Locked-In Syndrome

Locked-in syndrome is a rare neurological disorder characterized by complete paralysis of voluntary muscles in all parts of the body (except for those that control eye movement). It may result from traumatic brain injury, vascular diseases, demyelinating diseases, or medication overdose.

Individuals with locked-in syndrome are conscious and have cognitive function, but are unable to speak or move. The disorder leaves the patient completely mute and paralyzed. Communication may be possible with blinking eye movements.

There is no cure for locked-in syndrome, nor is there a standard course of treatment. Functional neuromuscular stimulation may help activate some paralyzed muscles. Several devices to help communication are available. Other treatment is symptomatic and supportive.

The prognosis for those with locked-in syndrome is poor. The majority of patients do not regain function.

Information provided by the
National Institute of Neurological Disorders and Stroke
National Institutes of Health

Each year, Medical College of Wisconsin physicians care for more than 180,000 patients, representing nearly 500,000 patient visits. Medical College physicians practice at Children's Hospital of Wisconsin, Froedtert Memorial Lutheran Hospital, the Milwaukee VA Medical Center, and many other hospitals and clinics in Milwaukee and southeastern Wisconsin.